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- August 2, 2017 at 2:13 pm #2507dave2048Participant
This is included in Wikipedia’s Narcolepsy page:
Abnormally low levels of acylcarnitine have been observed in people with narcolepsy. These same low levels have been associated with primary hypersomnia in general in mouse studies. “Mice with systemic carnitine deficiency exhibit a higher frequency of fragmented wakefulness and rapid eye movement (REM) sleep, and reduced locomotor activity.” Administration of acetyl-L-carnitine was shown to improve these symptoms in mice. A subsequent human trial found that narcolepsy patients given L-carnitine spent less total time in daytime sleep than patients who were given a placebo.
Does anybody have any experience with this? Did taking an alcar supplement help anybody?August 2, 2017 at 2:20 pm #2508TheRabbitKingKeymaster
Several of us had success with oral l-carnitine liquids. Myself, it seemed to tear up my gut too much to be worth the benefit.
My current jam: Anathema - SpringfieldAugust 2, 2017 at 7:16 pm #2511JasonKeymaster
@dave2048 I’ll look into it. I’m aware of the studies but my damned N memory leaves much to be desired. I’ll get back to you.August 4, 2017 at 8:12 am #2552JasonKeymaster
That study was done by the same researcher who reported low levels of acylcarnitine in pwn. I’d use l-carnitine over acetyl-l-carnitine since it restored the acetylcarnitine levels and has been studied in people, not just mice. They used 3 170mg l-carnitine capsules daily.
It’s interesting that 20% of pwn seem to be deficient. The author suspects a beta oxidation defect. It’s particularly interested because beta oxidation defects can cause neurological problems/damage and may explain some cases of N not associated with an autoimmune problem.
Just FYI, I would not exceed 500mg of carnitine since excessive doses may lower thyroid hormones. The best natural sources of carnitine are red meat, particularly lamb…yum!August 4, 2017 at 10:30 am #2562TheRabbitKingKeymaster
I always wonder if these N deficiencies in essential amino acids are direct causation, or if having N leads to poor general health or poor diet and that causes it.
My current jam: Anathema - SpringfieldAugust 4, 2017 at 11:27 am #2571JasonKeymaster
There’s a gene variant that regulates carnitine associated with N. It’s weird. There may be more than one way to develop N.
Of course since that research really wouldn’t lead to a pharmaceutical, there’s not much funding for it.
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