Drastic Increase in Xyrem Side Effects?

Index Support Center Forums Treating Narcolepsy Drastic Increase in Xyrem Side Effects?

This topic contains 2 replies, has 3 voices, and was last updated by Eleuthero 2 months, 2 weeks ago. This post has been viewed 158 times

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    Hey all,

    Just a quick question on Xyrem and new shipments.

    I’ve been on it a little over a month and I did really well and only experienced limited ill effects. Then, I get my new shipment last week and I’m suddenly extremely nauseous, dizzy, and vomiting first thing in the morning.

    I talked to the pharmacy and they said there haven’t been any other reports of issues. Basically, they wrote it off as normal and recommended contacting my doc to see about reducing the dose for while.

    Has anyone else experienced this kind of change in side effects very suddenly with a new shipment?


    Hey welcome to the forums. It would be helpful to know what dose you are currently on and how quickly you were titrated up to that dose. Sometimes to rapid titration will lead to the symptoms you describe.
    These symptoms may also be caused by the large mount of sodium in the drug.
    At any rate, give yourself a day off and see if the symptoms dissipate, if they continue then may not be related to the medication.
    All my best


    I had to quit Xyrem for many reasons, among which is that I started getting a motor tremor and my blood pressure rose from the 140/90 range to 180/105. I also developed a certain tolerance and had to move up to the highest end of the dosage range. Bottom line is that I chose to quit Xyrem. This stuff seems to produce different, and severe, side effects in a lot of people. It’s certainly not for everyone.


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