REM Sleep Behavior Disorder (RBD) and Narcolepsy

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    Sleepy RBD
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    After one of those nights, I decided to post a couple of quotes from one of the links I came across a few months ago in case someone else might be searching for information on this topic.

    RBD is reported to occur in NT1 with a frequency ranging between 7% and 63% in different cohorts (Schenck and Mahowald, 1992; Mayer and Meier-Ewert, 1993; Nightingale et al., 2005; Knudsen et al., 2010). RBD in NT1 is characterized by the lack of sex predominance, less complex and more elementary movements during REM sleep, less aggressive behavior in REM sleep, earlier age of onset, and hypocretin deficiency (AASM, 2014; Plazzi, 2018). RBD may also be precipitated or worsened by the pharmacological treatment of cataplexy with antidepressants. In pediatric patients, RBD may be an initial manifestation of NT1 (AASM, 2014). Although data on phenoconversion of narcolepsy-RBD into a synucleinopathy neurodegenerative disorder are lacking, cross-sectional studies are reassuring, since there has been no reported increased risk to develop neurodegenerative diseases in elderly narcolepsy-RBD patients.

    The association of RBD and narcolepsy has been considered as one of the multifaceted aspects of REM sleep motor dyscontrol of narcolepsy and was reported since the earliest RBD discovery and descriptions (Plazzi, 2018). Overall, narcolepsy is the second most frequent condition associated with RBD, after neurodegenerative diseases.

    Narcolepsy and RBD

    Another interesting link…
    The spectrum of REM sleep-related episodes in children with type 1 narcolepsy

    Hopefully, some of the above information will be helpful to someone else on this journey…

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