Tagged: high flow oxygen therapy
- This topic has 7 replies, 5 voices, and was last updated 10 months, 1 week ago by Myoak. This post has been viewed 1647 times
- August 14, 2018 at 3:32 pm #7278Pereise1Participant
So I had a couple ideas that may or may not work. The scientific evidence is there but the studies haven’t been carried out yet. So for my first idea:
- Sauna Use
So PWN have a growth hormone deficiency (Ref 1, 2, and 3). A GH deficiency is said to destroy your memory, sex drive, sense of self, among other things. So how to increase GH without getting into messy peptides and stuff? Well, Use of Sauna increases Growth Hormone. Also increases Vasopressin and Ghrelin (which increase Orexin) as well as endorphins. In another study with healthy volunteers, GH secretion rose by 16x compared to non-sauna users. So theoretically then, sauna use should improve sleep as well as wakefulness in PWN. I just signed up to a local gym with a sauna and had my first session yesterday. We’ll see how much it helps. Here’s a good summary of all the benefits and risks.
- Hyperbaric Oxygen Therapy
Now this one seems particularly illness/life changing. So the mechanism of action behind hyperbaric oxygen therapy (HBOT) is to flood the brain and body with oxygen. What this seems to do, is to induce rapid healing of scared or inflamed tissue. Among the many benefits of HBOT are lowering neuroinflammation (Ref) and because much of the fatigue in N is related to neuroinflammation, this is a promising treatment.
What’s more, as analyzed in the “Cure For Narcolepsy” thread, we all have scar tissue, or gliosis, in our hypothalamus. When our orexin neurons got attacked, they were covered over with scar tissue, preventing their regeneration. HBOT solves this problem by seemingly “reoxygenating” the tissue, causing a change in the scar tissue by having the scared neurons begin to change and sprout new neurons (Ref). Apparently this has the effect of “restoring locomotor activity” in brain damaged rats (Ref). Now could this possibly do the same in us by healing the scared tissue in our brains? No way to know for sure yet, but there’s been a lot of research into the healing effects of HBOT in strokes and traumatic brain injuries.
Here’s an additional article that goes into the benefits. I got a groupon for 3 sessions for $101 that I can use next week that I’m going to L.A., so I’ll try reporting back here as well.August 14, 2018 at 7:47 pm #7281FerretModerator
Fascinating! And thank you so much for providing links that explain your thought processes and back them up.
Please report back on the Hyperbaric Oxygen Therapy experience. I won’t do the sauna because I can’t tolerate heat but the oxygen therapy sounds promising (especially your first (ref)) AND I will be passing on that info to so many of my friends who have had TIA’s.February 14, 2019 at 3:22 pm #9095NatdocParticipant
I am a big fan of both sauna therapy and HBOT. We do offer sauna therapy at the clinic and plan to add HBOT as soon as we can. Just a note for those of you who cannot tolerate heat, the sauna is an infrared device so heat itself is not a problem. Our sessions run from 15 – 30 minutes. We actually have many patients who sit through a sauna therapy session about an hour prior to their sleep study we have found that it also helps promote delta sleep. I will attach information soon.
HBOT therapy is not new in general we have used it for quite some time to treat “bends” or decompression sickness and also to treat severe burns. It is beginning to be recognized for its uses in TIA, Stroke, MS and other neurodegenerative processes.
Of course the problem is going to be in getting access since insurance companies do not currently cover these therapies for Narcolepsy. or insomnia. We offer the therapy as part of an office visit; so far we have not been dinged for it but I’m sure at some point someone will have something to say about it.
These units are not all that expensive, I would suggest for those interested to trial a few sessions and see what happens, if useful then purchase may be an option. These units generally retail for about 2500.00.
I wish everyone the bestFebruary 21, 2019 at 1:05 pm #9173Pereise1Participant
So as a follow up for everyone, I do feel that the sauna use and the HBOT (6 times so far) in the last 6 months has made a difference. However, I’m not sure how helpful my personal experience with these is, as I’ve also been steadily detoxing from mold exposure as well. It’s tough to weed out which symptom is caused by Narcolepsy, and which is caused/exasperated by the mold. After each HBOT session, I do feel a lasting boost in wakefulness and dysautonomia. Regular use of the sauna, while sometimes giving me a flare up of mold symptoms due to increasing circulation of mycotoxins, has improved the slow wave sleep deficiency I normally experience. I’m gauging that based on improvements in the continuity of my sleep, increased muscle and skin healing, improved memory and mood. 3 or 4 times a week seems to be the sweet spot for me.April 12, 2019 at 1:28 pm #9781Pereise1Participant
Well, here’s a very recent study that finally links HBOT with Orexin:
The arousal effect of hyperbaric oxygen through orexin/hypocretin an upregulation on ketamine/ethanol-induced unconsciousness in male rats.
Approaches that facilitate the recovery from coma would have enormous impacts on patient outcomes and medical economics. Orexin-producing neurons release orexins (also known as hypocretins) energy-dependently to maintain arousal. Hyperbaric oxygen (HBO) could increase ATP levels by preserving mitochondrial function. We investigated, for the first time, the arousal effects of HBO and orexins mechanisms in a rat model of unconsciousness induced by ketamine or ethanol. A total of 120 Sprague-Dawley male rats were used in this study. Unconsciousness was induced either by intraperitoneal injection of ketamine or ethanol. The HBO treatment (100% O2 at 3 ATA) was administered immediately after unconsciousness induction for 1 hr. SB334867, orexin-1 receptor (OX1R) inhibitor, or JNJ10397049, orexin-2 receptor (OX2R) inhibitor was administered 30 min intraperitoneally before unconsciousness induction. Loss of righting reflex test (LORR) and Garcia test were used to evaluate the unconsciousness duration and neurological deficits after recovering from unconsciousness, respectively. Enzyme-linked immunosorbent assay was used to measure brain tissue ATP and orexin A levels. Ketamine or ethanol injection resulted in LORR immediately and neurological deficits 6 hr after unconsciousness induction. HBO treatment significantly reduced the LORR duration, improved Garcia scores and unregulated ATP and orexin A levels in the brain tissue. Administration of OX1R inhibitor or OX2 R inhibitor abolished arousal and neurological benefits of HBO. In conclusion, HBO exerted arousal-promoting effects on unconscious rats induced by ketamine or ethanol. The underlying mechanism was via, at least in part, ATP/orexin A upregulation. HBO may be a practical clinical approach to accelerate unconsciousness recovery in patients.April 14, 2019 at 10:15 am #9794PurpleyParticipant
A few notes on this abstract. First of all, what’s the source? (Journal citation, please.) Second, promoting orexin production from intact orexin-producing neurons on a temporary basis is only useful if you have those neurons (so N1s may won’t have much benefit if any, since those neurons are either severely diminished or gone); and if it does so by a clinically-relevant amount; and if it lasts for an extended period of time after you get out of the hyperbaric chamber. There are probably dozens (even hundreds) of things that increase orexin production temporarily, but if those three things aren’t the case then it’s not clinically useful.
So, hate to be a downer, but this is far from being relevant for treatment of N in humans."Even a soul submerged in sleep is hard at work and helps make something of the world."
― Heraclitus, FragmentsApril 15, 2019 at 1:08 pm #9814FerretModeratorNovember 18, 2019 at 11:18 am #11662MyoakParticipant
Hyperbaric oxygen therapy typically is performed as an outpatient procedure and doesn’t require hospitalization. If you’re already hospitalized and require high flow oxygen therapy, you’ll remain in the hospital for therapy.
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